Significant progress has been made in understanding the molecular pathology of uveal melanoma (UM). It is well known that genetic alterations, such as monosomy 3, polysomy 8q, and BAP1 gene-inactivating mutations, are associated with a poor prognosis in UM, whereas a gain in chromosome 6p is associated with a more favorable outcome.1 However, the pathways by which these genetic aberrations influence the processes involved in tumor dissemination and ultimate colonization are not fully understood.