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Invited Commentary
October 2016

Genetic Variants of the BTNL2 Gene in Uveal Melanoma

Author Affiliations
  • 1Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
JAMA Ophthalmol. 2016;134(10):1133-1134. doi:10.1001/jamaophthalmol.2016.2940

Significant progress has been made in understanding the molecular pathology of uveal melanoma (UM). It is well known that genetic alterations, such as monosomy 3, polysomy 8q, and BAP1 gene-inactivating mutations, are associated with a poor prognosis in UM, whereas a gain in chromosome 6p is associated with a more favorable outcome.1 However, the pathways by which these genetic aberrations influence the processes involved in tumor dissemination and ultimate colonization are not fully understood.