Herein, we describe a rare case of histiocytic sarcoma with choroidal involvement with immunohistochemical and genetic confirmation. To our knowledge, this is the first report of histiocytic sarcoma with intraocular involvement in the human eye.
A middle-aged man was admitted to a regional hospital with acute sinusitis, tonsillitis, and increasing dysphagia and dyspnea. Recently, he had been investigated for malaise, generalized lymphadenopathy, and anemia. The patient presented to the ophthalmology department for painless blurred vision in the left eye. On examination, he had a central scotoma in the left eye, but his visual acuity was 6/6 OU. Subtle subretinal fluid in the left eye, consistent with central serous chorioretinopathy, was noted on fundus images and confirmed by ocular coherence tomography. There was no intraocular inflammation; thus, management involved observation. Meanwhile, a histological examination of nasal and bone-marrow biopsies revealed histiocytic sarcoma.
Krishna Y, Araujo I, Warrier S, Heimann H, Coupland SE. Diffuse Histiocytic Sarcoma Involving the Choroid. JAMA Ophthalmol. 2016;134(10):1198–1200. doi:10.1001/jamaophthalmol.2016.2867
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