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Invited Commentary
October 2016

Abrasions, Planned Defects, and Persistent Epithelial Defects in Corneal Epithelial Wound Healing

Author Affiliations
  • 1Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore
JAMA Ophthalmol. 2016;134(10):1176-1177. doi:10.1001/jamaophthalmol.2016.3086

Corneal epithelial wound healing is a seemingly simplistic process that in reality is quite complex depending on the circumstances: the proliferation, migration, and adhesion of epithelial cells occur differently under various conditions of inflammation, infection, and underlying stromal processes. As such, therapies to heal traumatic corneal abrasions, planned corneal epithelial defects such as postphotorefractive keratectomy (PRK), and persistent epithelial defects (PED) may require addressing different mechanisms. Because of the possible consequences of epithelial defects, such as infection, scarring, corneal melting, and even perforation, all potentially leading to loss of vision, interest in healing corneal epithelial defects is high.