Oral Fluoroquinolone Use and Retinal Detachment

To the Editor We read with interest the recent article by Raguideau et al¹ on the association between the use of fluoroquinolone antibiotics and retinal detachment. The authors chose to use 2 self-controlled study designs to address this question: first, the case crossover method,² and, second, the self-controlled case series.³ The 2 methods appear to give similar answers, suggesting a roughly 50% increased risk of retinal detachment following exposure to a fluoroquinolone. However, we have some concerns about the method underpinning the study.