Ho and colleagues1 studied the cross-sectional associations between common systemic medication use and intraocular pressure (IOP) in the Singapore Epidemiology of Eye Diseases (SEED) study of a population-based cohort. Examining associations with systemic medications is of interest for 2 main reasons. First, understanding such associations may guide our management of patients with glaucoma who are receiving treatment for systemic comorbidities. Second, unexpected associations may point to previously unknown biological mechanisms underlying the regulation of IOP, which may in turn lead to new treatments.