In Reply I thank Dr Sparrow for responding to my commentary1 on the study of Gliem et al2 demonstrating lower levels of fundus autofluorescence in eyes with age-related macular degeneration using a new technique, quantitative autofluorescence. We agree that longitudinal studies of patients with normal and age-related macular degeneration maculas are needed to understand the clinical relevance of variation in quantitative autofluorescence levels.
Smith RT. Quantitative Fundus Autofluorescence—Reply. JAMA Ophthalmol. 2017;135(4):403–404. doi:10.1001/jamaophthalmol.2017.0121
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