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Invited Commentary
May 2017

The Draw(backs) of Big Data

Author Affiliations
  • 1F. I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, San Francisco
JAMA Ophthalmol. 2017;135(5):422-423. doi:10.1001/jamaophthalmol.2017.0703

The association between psoriatic arthritis and uveitis is well-known. Intraocular inflammation in psoriatic arthritis is found among up to 25% of patients seen at tertiary rheumatology centers.1 To our knowledge, however, less is known about the association between uveitis and psoriasis without arthritis. Some have noted differences in the onset and clinical features of uveitis between patients with psoriasis and psoriatic arthritis.2 This is interesting given that while psoriatic arthritis is a seronegative spondyloarthropathy, psoriasis without arthritis is not. However, among patients with psoriasis, the prevalence of psoriatic arthritis is certainly higher than in the general population.3 Interestingly, 1 epidemiologic study noted that the presence of uveitis in a patient with psoriasis increased the risk of that patient developing psoriatic arthritis substantially more than the severity of the psoriasis or the presence of nail pitting.4