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Comment & Response
July 2017

Incorporating Clinical, Histological, and Genetic Parameters for Choroidal Melanoma Prognostication

Author Affiliations
  • 1Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, England
  • 2Royal Liverpool University Hospital, Liverpool, England
  • 3Ocular Oncology Service, University of California–San Francisco, San Francisco
JAMA Ophthalmol. 2017;135(7):818-819. doi:10.1001/jamaophthalmol.2017.1391

Walter et al1 recently reported that tumor diameter measurement enhances the prediction of metastatic disease from class 2 uveal melanoma (UM), as classified with gene expression profiling. They advocate combining these 2 predictors when estimating prognoses.

We agree with this recommendation. Since 2007, we have published several articles emphasizing the importance of combining clinical, histologic, and genetic survival predictors when estimating a prognosis for UM posttreatment.2 We developed an online prognostic tool predicting survival using multivariable analyses, also accounting for age and sex.2 Walter et al1 have not cited these articles, so their Discussion does not interpret their results by taking into consideration all other relevant evidence in the literature.

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