A 66-year-old white woman presented with a 2-month history of a “cloudy spot” in her left eye. She denied eye pain, transient vision loss, photophobia, or photopsias but reported right-sided jaw pain migrating to include both temples, ears, neck, and left shoulder. The jaw became more painful and fatigued with chewing, associated with an 3.6-kg weight loss over 3 months. A mouth guard prescribed by her dentist for temporomandibular joint disease had provided substantial relief over the past 2 months. She denied any history of hypertension, hyperlipidemia, type 2 diabetes, or human immunodeficiency virus exposure but had a 20 pack/year cigarette smoking history.