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Comment & Response
August 2017

Using Rho Kinase Inhibitors for Retinal Detachment

Author Affiliations
  • 1Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School, Rutgers University, Newark
  • 2Institute of Ophthalmology and Visual Science, New Jersey Medical School, Rutgers University, Newark
JAMA Ophthalmol. 2017;135(8):895. doi:10.1001/jamaophthalmol.2017.2276

To the Editor We applaud the efforts by Simunovic and colleagues1 to examine the issue of structural and functional recovery of the retina after an iatrogenic macular detachment. An injection of adeno–associated viral vector that encoded Rab escort protein 1 into 5 patients with choroidermeia yielded mixed results: visual acuity was restored among all patients, but sensitivity and color discrimination did not improve consistently. As this study assesses recovery only up to 1 month after reattachment, it is possible that many or all of the residual abnormalities noted after macular detachment will reverse. One factor that may limit visual recovery, however, is detachment-induced synaptic retraction.

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