To the Editor We have read the article by Wakamatsu and colleagues1 that was published in JAMA Ophthalmology. The authors evaluated the association between human leukocyte antigen class I genes and cold medicine–associated Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications. One of their main findings was that human leukocyte antigen-A*66:01 was associated with cold medicine–associated Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications among Europeans (odds ratio [OR], 21.2; 95% CI, 0.97-465.0; P = .04), which is questionable. The scientists consider an association to be statistically significant when its P value is less than .05 or its confidence interval (CI) has not crossed 1.2 In the aforementioned association reported by Wakamatsu et al,1 the CI had crossed 1, whereas its corresponding P value was reported to be less than .05, which is controversial and should be corrected.
Ayubi E, Safiri S. Data Sparsity in Study on Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications . JAMA Ophthalmol. 2017;135(8):893–894. doi:10.1001/jamaophthalmol.2017.2286
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