In Reply We thank Townes-Anderson and colleagues for their insightful letter in response to our recent publication.1 Our work investigates changes in retinal structure, spatial vision, contrast detection/threshold sensitivity, color discrimination, and color matching following limited iatrogenic detachment of the macula in 5 consecutively treated men as a part of a phase I/II trial of gene therapy for choroideremia (NCT01461213). We demonstrated that retinal reattachment occurred within 1 week of the procedure and that best-corrected visual acuity recovered by 1 month in all 5 participants. One patient was observed to have altered color matching at all follow-up points and 2 demonstrated reductions in threshold sensitivity at 1 month.
Simunovic MP, Xue K, MacLaren RE. Using Rho Kinase Inhibitors for Retinal Detachment—Reply. JAMA Ophthalmol. 2017;135(8):895–896. doi:10.1001/jamaophthalmol.2017.2283
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