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October 2017

Ocular Surface Squamous Neoplasia in a Patient With Hepatitis C

Author Affiliations
  • 1Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston
  • 2Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
  • 3David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston
  • 4Schepens Eye Research Institute, Boston, Massachusetts
JAMA Ophthalmol. 2017;135(10):1121-1123. doi:10.1001/jamaophthalmol.2017.2967

Ocular surface squamous neoplasia (OSSN) is associated with UV radiation, human immunodeficiency virus (HIV), and human papilloma virus (HPV) infections.1 In this article, we demonstrate a potentially new association between OSSN and hepatitis C virus (HCV). This novel finding has implications for oncogenesis of OSSN and ocular manifestations of HCV infection.

A woman in her 80s with a history of chronic HCV infection (viral load, 2.5 million IU/mL) presented with a 2-week history of bleeding from the right eye. She had a history of amblyopia, corneal neovascularization secondary to radial keratotomy, and cataract surgery with subsequent pseudophakic bullous keratopathy. She was recommended to undergo a penetrating keratoplasty but was lost to follow-up.