The emergence of optical coherence tomographic angiography (OCTA) has been met with excitement, especially with the opportunity to visualize detail of the microvascular morphology of neovascular lesions originating from the retina and choroid.1 However, our initial enthusiasm has been partially dulled by the challenges encountered with this complex technology, not least of which are the struggles related to the accuracy of quantitative measurements, notably vessel density analysis of the retinal capillary plexus. Lei et al2 should be commended for their work in this issue of JAMA Ophthalmology in which they provide substantive data regarding the repeatability and reproducibility of quantitative OCTA measurements and raise awareness of the importance of validating OCTA methods and identify potential confounders of data acquisition and analysis.
Garrity ST, Sarraf D. The Arc of Change in Optical Coherence Tomographic Angiography Technology: Progression Toward Greater Reliability. JAMA Ophthalmol. 2017;135(10):1098–1099. doi:10.1001/jamaophthalmol.2017.3444
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