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December 2017

Intracameral Topotecan Hydrochloride for Anterior Chamber Seeding of Retinoblastoma

Author Affiliations
  • 1Ocular Oncology Service, Bascom Palmer Eye Institute, Miami, Florida
  • 2Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida
JAMA Ophthalmol. 2017;135(12):1453-1454. doi:10.1001/jamaophthalmol.2017.4603

Anterior chamber seeding is a high-risk characteristic of retinoblastoma that often results in enucleation. We describe the complete and sustained regression of anterior chamber tumor seeding using an intracameral injection of topotecan hydrochloride in the better-seeing eye of a child with bilateral retinoblastoma.

A 9-month-old girl presented with International Classification of Retinoblastoma1 group A retinoblastoma in the right eye and group C retinoblastoma in the left eye. The left eye was treated with 3 sessions of intra-arterial chemotherapy using melphalan hydrochloride, 4 mg, carboplatin, 30 mg, and topotecan hydrochloride, 0.3 mg, followed by diode laser therapy, which resulted in stable tumor regression but limited visual potential due to a calcified tumor remnant in the macula.