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Invited Commentary
November 9, 2017

Mantle-Cell Lymphoma—Taming the Tiger

Author Affiliations
  • 1Ocular Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania
JAMA Ophthalmol. Published online November 9, 2017. doi:10.1001/jamaophthalmol.2017.4290

Mantle-cell lymphoma is an untamed tiger. A collaborative effort investigating conjunctival lymphoma in 263 patients from an ophthalmic perspective1 noted that most periocular lymphomas are fairly low grade. Not so for mantle-cell lymphoma. This relatively uncommon form of lymphoma is particularly dangerous. The analysis found an overwhelming predominance of B cell–type lymphoma (although rare T–cell lymphoma has also been recognized) and identified the specific lymphoma subtype, including low-grade forms such as extranodal marginal zone lymphoma (n = 180; 68%) and follicular lymphoma (n = 43; 16%) and high-grade forms such as mantle-cell lymphoma (n = 18; 7%) and diffuse large B-cell lymphoma (n = 12; 5%).1 Outcomes paralleled disease subtype. Five-year disease-specific survival was favorable for extranodal marginal zone lymphoma (97%) and follicular lymphoma (82%), but strikingly unfavorable for diffuse large B-cell lymphoma (55%) and especially mantle-cell lymphoma (9%), which is plagued with recurrences and displays poor outcome.

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