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Invited Commentary
February 2018

Analysis of the Association Between Physical Activity and Age-Related Macular Degeneration

Author Affiliations
  • 1Centre for Eye Research Australia, East Melbourne, Australia
  • 2Department of Surgery, University of Melbourne, East Melbourne, Australia
  • 3Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
  • 4Department of Ophthalmology, University of Bonn, Bonn Germany
JAMA Ophthalmol. 2018;136(2):139-140. doi:10.1001/jamaophthalmol.2017.4782

Choroidal neovascularization resulting from age-related macular degeneration (AMD) is a major cause of blindness among the elderly residing in developed nations. Current interventions for neovascular AMD can be costly and cause patient distress and are not without the potential for adverse effects.1 Thus, the quest to identify modifiable risk factors for AMD is important, with the potential to assist in the prevention or delay of AMD progression. In this issue of JAMA Ophthalmology, Rim and coauthors2 report their unexpected finding of a 1.2-fold increase in the incidence of neovascular AMD (95% CI, 1.02-1.49) among participants who exercised vigorously, using data from a large cohort (211 960 participants) of the Korean National Health Screening Program. The authors are understandably cautious in their interpretation of the results because of the observational nature of the study and the problems associated with self-reported measures of activity.