In Reply We thank Bhudia for her interest. At her suggestion we completed additional analyses, and there do not appear to be substantial differences in the sensitivity of the Children’s Hospital of Philadelphia Retinopathy of Prematurity (CHOP ROP) model among subgroups defined by maternal race or study center, although the sample sizes were small in some of the subgroups. However, this finding is not surprising, as for a factor, such as race or center, to confound the relations between severe ROP and the predictive variables in the CHOP ROP model (birth weight, gestational age, and postnatal weight gain), the factor must be related not only to severe ROP but also to the predictive variables, which is not clearly the case.
Binenbaum G, Ying G. Role of Maternal Race on Algorithms Predicting Retinopathy of Prematurity—Reply. JAMA Ophthalmol. 2018;136(2):221–222. doi:10.1001/jamaophthalmol.2017.5692
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