A female patient with a history of premature birth (24 weeks’ gestational age, 538 g) and zone I, stage 3 retinopathy of prematurity (ROP) with plus disease treated with a single injection of 0.625 mg of intravitreal bevacizumab in each eye presented for routine examination at 2 years of age. Examination with the patient under anesthesia with fluorescein angiography (Figure 1) revealed significant peripheral retinal avascularity, circumferential vascular loops at the border of vascular and avascular retina, and arteriovenous anastomoses in both eyes. There was no evidence of retinal neovascularization or recurrence of ROP.
Shah N, Gupta MP, Chan RVP. Persistent Angiographic Abnormalities After Intravitreal Anti–Vascular Endothelial Growth Factor Therapy for Retinopathy of Prematurity. JAMA Ophthalmol. 2018;136(4):436–437. doi:10.1001/jamaophthalmol.2017.4172
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