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Comment & Response
April 2018

Methodological and Efficacy Issues in a Randomized Clinical Trial Investigating Vitreous Floater Treatment

Author Affiliations
  • 1Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland
  • 2Department of Ophthalmology, Medical University of Gdańsk, Gdańsk, Poland
JAMA Ophthalmol. 2018;136(4):449. doi:10.1001/jamaophthalmol.2018.0215

To the Editor We have read the article by Shah and Heier1 with great interest. However, we believe some discussion might be beneficial. The authors present the results of a randomized clinical trial comparing YAG vitreolysis vs sham YAG vitreolysis for symptomatic vitreous floaters. Although, according to the Methods section, intraocular pressure (IOP) was to be measured in all follow-up examinations, no particular results of these measurements were presented. The Results section includes only a short statement that IOP elevations did not occur in any of the patients’ eyes. However, the issue of any relative increase in the IOP in any of the visits was never explored.

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