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Comment & Response
April 2018

Why Space Flight–Associated Neuro-ocular Syndrome May Differ From Idiopathic Intracranial Hypertension

Author Affiliations
  • 1Department of Psychiatry, Psychiatrisch Centrum Sint-Amandus, Beernem, Belgium
  • 2Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
  • 3Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands
  • 4Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium
JAMA Ophthalmol. 2018;136(4):451-452. doi:10.1001/jamaophthalmol.2018.0316

To the Editor We very much appreciate the paper recently published in JAMA Ophthalmology by Lee et al.1 In line with the idea that increased intracranial pressure (ICP) may not be the sole, or even the primary, cause of optic disc swelling in astronauts, the authors discuss important differences between space flight-associated neuro-ocular syndrome (SANS) and (terrestrial) idiopathic intracranial hypertension (IIH) and emphasize that postmission lumbar puncture opening pressures measured thus far were only mildly elevated. Based on the latest evidence from research, we believe there may be a plausible explanation for why SANS may differ from IIH.

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