To the Editor We very much appreciate the paper recently published in JAMA Ophthalmology by Lee et al.1 In line with the idea that increased intracranial pressure (ICP) may not be the sole, or even the primary, cause of optic disc swelling in astronauts, the authors discuss important differences between space flight-associated neuro-ocular syndrome (SANS) and (terrestrial) idiopathic intracranial hypertension (IIH) and emphasize that postmission lumbar puncture opening pressures measured thus far were only mildly elevated. Based on the latest evidence from research, we believe there may be a plausible explanation for why SANS may differ from IIH.
Wostyn P, De Deyn PP. Why Space Flight–Associated Neuro-ocular Syndrome May Differ From Idiopathic Intracranial Hypertension. JAMA Ophthalmol. 2018;136(4):451–452. doi:10.1001/jamaophthalmol.2018.0316
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