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Comment & Response
May 2018

Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma—Reply

Author Affiliations
  • 1The Vision Center at Children’s Hospital Los Angeles, Los Angeles, California
  • 2University of Southern California Roski Eye Institute, Keck Medical School of the University of Southern California, Los Angeles
  • 3Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles
  • 4Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles
  • 5The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California
  • 6Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles
JAMA Ophthalmol. 2018;136(5):598. doi:10.1001/jamaophthalmol.2018.0395

In Reply In a letter published in this issue of JAMA Ophthalmology, Uner et al comment on the new horizon for genetic analyses of retinoblastoma tumors brought forth by our study1 on the possibility of biopsying aqueous humor for retinoblastoma. The study presented a proof of principle that the aqueous humor (AH) can serve as a liquid biopsy (in other words, as a surrogate to tumor biopsy) for retinoblastoma, which cannot otherwise be safely accessed in vivo. If tumor-derived DNA can be routinely extracted from the AH in patients who have retinoblastoma, it has potential to alter the way we manage this disease. We agree with Uner et al that, on any new horizon, one must proceed cautiously and with a clear vision.

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