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September 2001

Selective Citation of Evidence Regarding Photoreceptor Loss in Glaucoma

Arch Ophthalmol. 2001;119(9):1391. doi:

In reply

We thank Dr Quigley for his insightful comments regarding our article. He is correct in his assertion that we did not provide a detailed review of the literature regarding possible outer retinal involvement in glaucoma. However, we did refer to an earlier publication by Nork et al1 in which the articles by Panda and Jonas2 and Kendell et al3 were cited. Our goal was to provide some background information about the anterograde hypothesis and to explain why we chose this particular experimental protocol to test it. The hypothesis states that the effects of outer retinal injury (possibly owing to an intraocular pressure–related decrease in choroidal circulation) may be transmitted in an anterograde manner to adversely affect ganglion cell survival. Although photoreceptor loss is not a necessary element for this to take place, photoreceptor injury is.

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