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September 2001

Corticosteroid and Antibiotic Therapy for Bacillus Endophthalmitis

Author Affiliations

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Ophthalmol. 2001;119(9):1392-1393. doi:

In reply

We thank Callegan and colleagues for their interest in our study. As reflected in their letter, the role of corticosteroids in the treatment of endophthalmitis remains controversial.

As Callegan and colleagues are aware, in some cases the review process precludes identification of all relevant articles prior to the date of publication. Of the 5 citations they mentioned as not cited in our study, 1 dealt with endophthalmitis caused by a toxin-producing bacterium. This article underscores the importance of toxins in infectious disease but covers Enterococcus faecalis, not Bacillus strains.1 Two of the cited omissions were likely published after our submission.2,3 In the article by Yoshizumi et al,4 there was a positive response to dexamethasone sodium phosphate treatment for experimental Staphylococcus aureus endophthalmitis, so we do not feel that this represents an omission in stating a contrary viewpoint. We appreciate Callegan and colleagues bringing several of these valuable citations to the public's attention, especially the one by Meredith et al5 that was not cited in our original article.