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Invited Commentary
June 2018

The Ophthalmic Sequelae of Ebola

Author Affiliations
  • 1Ocular Inflammatory Disease Center, UCLA Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles
  • 2Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles
  • 3Center for Global and Immigrant Health, Department of Epidemiology, UCLA Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles
  • 4The University of California, Los Angeles–Democratic Republic of Congo Health Research and Training Program, Kinshasa, Democratic Republic of Congo
JAMA Ophthalmol. 2018;136(6):693-694. doi:10.1001/jamaophthalmol.2018.1237

In this issue of JAMA Ophthalmology, Steptoe et al1 describe in detail the characteristics of a specific retinal lesion type found in 14 survivors of Ebola virus disease, using various imaging techniques, including ultra-widefield scanning laser ophthalmoscopy, fundus autofluorescence, and swept-source optical coherence tomography. Structural analysis demonstrated disruption of the outer retina with perilesional ellipsoid zone hyporeflectivity. Spatial analysis suggested that lesions are located along axons in the nerve fiber layer. This article is a follow-up to their 2017 article,2 in which they found several types of retinal lesion in survivors of Ebola virus disease. But among those lesion types, the particular type in this article1 was found only in survivors compared with a large group of control participants.

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