Although infection with varicella-zoster virus (VZV) has been known
to cause occlusive retinal arteritis leading to acute retinal necrosis1 in both immunocompetent and immunocompromised patients,
retinal periphlebitis is a rare manifestation of varicella-zoster ophthalmicus.
We examined 2 immunocompetent patients with unilateral retinal periphlebitis
and iridocyclitis without cutaneous eruptions associated with positive VZV
genomes in the aqueous fluid. One patient had a fundus appearance compatible
with that of frosted branch angiitis, suggesting a possible correlation between
one form of frosted branch angiitis and a VZV infection.
Noda Y, Nakazawa M, Takahashi D, Tsuruya T, Saito M, Sekine M. Retinal Periphlebitis as Zoster Sine Herpete. Arch Ophthalmol. 2001;119(10):1550–1552. doi:
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