Although choroidal invasion in eyes with retinoblastoma is commonly seen through pathological examination, it has rarely been identified with ophthalmoscopy or ultrasonography. Over a 2-month period, a 6-year-old girl who had been treated for bilateral retinoblastoma with systemic chemotherapy, intra-arterial chemotherapy, laser therapy, cryotherapy, and brachytherapy developed a dome-shaped brown-orange fundus lesion that was speckled on its surface with overlying serous retinal detachment (Figure, A). Extension along a ciliary nerve was suspected, and an enucleation was performed. Pathological examination showed that the mass represented massive choroidal invasion without extension into the ciliary body but tracking of tumor cells along a ciliary nerve (Figure, B).
Abramson DH, Folberg R, Francis JH. Clinicopathological Correlation of Choroidal Invasion in Retinoblastoma. JAMA Ophthalmol. 2018;136(6):e180940. doi:10.1001/jamaophthalmol.2018.0940
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