A 48-year-old white woman presented with a sudden, painless decrease in the vision of her left eye. Her visual acuity was 20/100. Results of an anterior segment evaluation were normal. Fundus examination revealed a bilobed, elevated lesion nasal to the optic disc with an amelanotic portion and a darkly pigmented one (Figure). Ultrasonography revealed a mass consistent with choroidal melanoma with a basal diameter of 17.5 mm and thickness of 7.97 mm. A systemic workup revealed no evidence of metastatic disease. She underwent episcleral brachytherapy with an iodine 125 plaque. Brachytherapy was followed by tumor regression documented by ultrasonography 3 months after the treatment. After the first year, she maintained the visual acuity noted before treatment, with regression more readily apparent within the amelanotic portion of the lesion.
Silva AMM, Fonseca MCF, Proença RD. Amelanotic and Pigmented Uveal Melanoma. JAMA Ophthalmol. 2018;136(7):e181114. doi:10.1001/jamaophthalmol.2018.1114
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: