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Invited Commentary
September 2018

The Cilioretinal Artery—A Friend to Age-Related Macular Degeneration?

Author Affiliations
  • 1Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland
JAMA Ophthalmol. 2018;136(9):1015-1016. doi:10.1001/jamaophthalmol.2018.2644

In this issue of JAMA Ophthalmology, Snyder et al1 report the association of cilioretinal artery with both the prevalence and incidence of late age-related macular degeneration (AMD) in the Age-Related Eye Disease Study. The investigators found that the presence of cilioretinal artery detected by baseline color fundus photographs was associated with a statistically significant reduction in both the prevalence and incidence of neovascular AMD in analyses of 3647 study participants. For those with cilioretinal artery, the prevalent cases had a lower baseline AMD severity score than those participants without cilioretinal artery. However, the mean change in progression of the AMD severity score was not significantly different at 5 years. There were also no statistically significant differences between eyes with or without cilioretinal artery for both prevalent and incident central geographic atrophy associated with AMD.

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