In this issue of JAMA Ophthalmology, Snyder et al1 report the association of cilioretinal artery with both the prevalence and incidence of late age-related macular degeneration (AMD) in the Age-Related Eye Disease Study. The investigators found that the presence of cilioretinal artery detected by baseline color fundus photographs was associated with a statistically significant reduction in both the prevalence and incidence of neovascular AMD in analyses of 3647 study participants. For those with cilioretinal artery, the prevalent cases had a lower baseline AMD severity score than those participants without cilioretinal artery. However, the mean change in progression of the AMD severity score was not significantly different at 5 years. There were also no statistically significant differences between eyes with or without cilioretinal artery for both prevalent and incident central geographic atrophy associated with AMD.