Volpe et al1 retrospectively reviewed
the records of 27 women at 2 institutions who were diagnosed as having unilateral
acute idiopathic blind spot enlargement syndrome (AIBSE). The patients were
referred by comprehensive ophthalmologists or retinal specialists because
a diagnosis could not be established. No information was provided concerning
the interval between the onset of symptoms and the authors' examination. Each
patient had a history of acute onset of visual disturbance, and each had demonstrable
blind spot enlargement (BSE) in 1 eye on visual field testing. The BSE was
not caused by optic disc swelling. Although no other criteria for patient
recruitment or exclusion were given, the 100% unilateral involvement in women
suggests that sex and unilaterality may have been factors. Less than half
of the patients had fundus photographs or fluorescein angiography. Only one
third had either full-field electroretinography (ERG), focal ERG, or both.
One patient had a normal focal ERG result that seemed incompatible with receptor
cell damage in the juxtapapillary region. Only 10 (37%) of the patients had
follow-up, and for an unstated length of time. The authors concluded that
the striking predilection for the peripapillary retina distinguishes AIBSE
from multiple evanescent white dot syndrome (MEWDS) and that unlike patients
with MEWDS, recovery of the visual field does not occur in patients with AIBSE.
They further concluded that AIBSE is a nonprogressive condition that is distinct
from MEWDS, acute zonal occult outer retinopathy (AZOOR), acute macular neuroretinopathy
(AMN), and multifocal choroiditis with panuveitis.
Gass JDM. Overlap Among Acute Idiopathic Blind Spot Enlargement Syndrome and Other Conditions. Arch Ophthalmol. 2001;119(11):1729–1730. doi:
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