A woman in her mid-50s was admitted for treatment of squamous cell carcinoma in the right maxillary sinus (T4a, N0 to M0, stage IVA). Findings of an ocular fundus evaluation conducted before external beam radiation therapy were unremarkable (Figure, A). The patient had no medical history of diabetes, hypertension, or systemic vascular disease. As chemotherapy, a single 240-mg dose of cisplatin was infused intra-arterially. On the next day, external beam radiation therapy was administered using a 4-megavolt x-ray produced by a linear accelerator. The daily fraction size was 2 Gy, which was delivered 5 days per week for 6 weeks (30 fractions), with a total dose of 60 Gy. Fundus examination conducted 2 months after completion of radiotherapy revealed widespread punctate pigment abnormalities consistent with radiation-related retinal pigment epitheliopathy (Figure, B). The patient’s visual acuity deteriorated to no light perception.
Usui Y, Mizusawa T, Goto H. Punctate Retinal Pigment Epitheliopathy and Choroidopathy After Radiotherapy With Chemotherapy. JAMA Ophthalmol. 2018;136(8):e181754. doi:10.1001/jamaophthalmol.2018.1754
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.