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February 2002

Retinal Detachment and Culture-Proven Bacterial Endophthalmitis in the EVS

Arch Ophthalmol. 2002;120(2):230-231. doi:

In reply

We appreciate the letter from Drs Enzenauer and Biderman concerning the incidence of retinal detachment in the EVS. The article published on this topic1 showed that 8% of patients undergoing treatment for post–cataract extraction endophthalmitis developed a retinal detachment. The incidence of retinal detachment, an adverse effect of endophthalmitis or its treatment, did not differ significantly between those treated with vitrectomy and those treated with tap/biopsy. However, study data showed that the retinal detachment rate was 11% (24/214) in those not treated with IV antibiotics vs 5% (11/206) among eyes treated with IV antibiotics. We could not explain the latter difference with any reasonable medical hypothesis. We postulated that the finding of this difference might be a type I error (ie, a false-positive finding due to chance). Statistical hypothesis testing at the P<.05 level indicates that once in every 20 times a false positive will occur by chance alone.