In reporting the results from large clinical trials, once the primary
question has been answered (which has been the case with the EVS1),
exploratory data analyses are carried out to generate hypotheses for further
research. Diabetes is epidemic and is a disease with major public health implications.
As patients with diabetes live longer, develop more cataracts, and undergo
cataract extraction, the question of endophthalmitis in this patient population
is appropriate to study. As it turns out, the EVS cohort is the largest published
series of postcataract endophthalmitis in a population of patients with diabetes.
The goal of the EVS in examining the data concerning patients with diabetes
was to describe the findings of endophthalmitis in this set of patients, and
to search for clinically important leads to be further investigated.
Kelsey SF, Doft BH, Wisniewski SR, Groer-Fitzgerald S, Endophthalmitis Vitrectomy Study Group. Diabetes and the EVS: A Different Interpretation of the Results. Arch Ophthalmol. 2002;120(2):232–233. doi:
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