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Invited Commentary
October 2018

Core Outcome Sets for Clinical Trials in Dry Eye Disease

Author Affiliations
  • 1Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand
JAMA Ophthalmol. 2018;136(10):1180-1181. doi:10.1001/jamaophthalmol.2018.3361

The release of the first Tear Film and Ocular Surface Society Dry Eye Workshop (TFOS DEWS) report in 2007 marked a watershed moment that prompted widespread recognition of dry eye disease and its increasing burden globally.1 With exponential growth in interest in the field, the volume of literature devoted to dry eye disease almost doubled by the time of publication of the second TFOS Dry Eye Workshop (TFOS DEWS II) a decade later.1 However, the TFOS DEWS II reports consistently identify the methodological heterogeneity in outcome measures used for screening, diagnosing, and monitoring dry eye disease in clinical research as creating significant challenges in evidence synthesis and interpretation.1,2

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