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Comment & Response
November 2018

Incidence and Causes of Overdiagnosis of Optic Neuritis: Physician Insecurity—Reply

Author Affiliations
  • 1Department of Neurology, Washington University School of Medicine, St Louis, Missouri
  • 2Blue Sky Neurology, Denver, Colorado
  • 3Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
JAMA Ophthalmol. 2018;136(11):1312-1313. doi:10.1001/jamaophthalmol.2018.3485

In Reply We thank Abdulhussein et al for reading our article1 and for their comments. We would also like to thank the editors for the opportunity to reply.

We chose to use the term overdiagnosis in our study rather than the term misdiagnosis, because we were interested in analyzing all patients referred to us with a diagnosis of optic neuritis. This subsequently allowed us to identify factors that were more likely to correspond with a true diagnosis of optic neuritis (eg, an age younger than 50 years and the presence of an afferent pupillary defect) in addition to other factors that may have led to an inaccurate initial diagnosis.

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