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Invited Commentary
November 2018

Anti-VEGF Neovascular Age-Related Macular Degeneration Treatment Adherence Requires Attention and Action

Author Affiliations
  • 1Department of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor
  • 2Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor
JAMA Ophthalmol. 2018;136(11):1260-1261. doi:10.1001/jamaophthalmol.2018.3595

The ability to offer hope to patients with vision loss due to neovascular age-related macular degeneration (nAMD) by administering frequent intravitreal injections of anti–vascular endothelial growth factor (VEGF) has drawn attention toward identifying the optimal frequency of injections. While the labeling of 2 approved anti-VEGF agents calls for administering an injection once a month, pro re nata1 or treat-and-extend2 regimens are commonly applied in clinical practice. However, all of this attention to optimizing the injection frequency is a moot issue if patients fail to come back at the intervals that are needed for follow-up.

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