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Invited Commentary
November 2018

Survival Analysis and the Immortal Time Bias

Author Affiliations
  • 1Jaeb Center for Health Research, Tampa, Florida
JAMA Ophthalmol. 2018;136(11):1314-1315. doi:10.1001/jamaophthalmol.2018.3499

In the current issue of JAMA Ophthalmology, Tseng et al1 report an error in their analysis that had originally concluded that cataract surgery was associated with improved survival among older women diagnosed as having a cataract.2 The corrected analysis, in fact, suggests the opposite conclusion that surgery may be associated with reduced survival among these women. This provides us a good learning opportunity to review the statistical issues involved in this case and better understand the potential pitfalls with these types of analyses.

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