IN A CLASSIC Peanuts cartoon, Lucy declares triumphantly that "with nothing more than a simple eye patch, we have brought amblyopia to its knees." Elegant in its simplicity, occlusion of the sound eye has remained an effective and standard treatment of amblyopia since it was initially described in the middle of the 18th century.1 Despite this, amblyopia still is one of the leading causes of monocular blindness in people between the ages of 20 and 70 years.1 More recently, atropine sulfate to blur the sound eye, a treatment referred to as "pharmacologic penalization," has been advocated as an alternative to traditional occlusion therapy.
Kushner BJ. Atropine vs Patching for the Treatment of Moderate Amblyopia in Children. Arch Ophthalmol. 2002;120(3):387–388. doi:10.1001/archopht.120.3.387
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