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Comment & Response
December 2018

Clarification on Uveal Melanoma Associated With Myotonic Dystrophy

Author Affiliations
  • 1Department of Medicine Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy
  • 2Cardiomyology and Medical Genetics, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli,” Naples, Italy
JAMA Ophthalmol. 2018;136(12):1425-1426. doi:10.1001/jamaophthalmol.2018.4053

To the Editor We read with great interest the article by Dalvin et al1 concerning the association between myotonic dystrophy (DM1) and uveal melanoma. Recent evidence has shown that uveal melanoma is associated with mutations in genes responsible for the eye colors, with a higher disease prevalence in individuals with lighter-colored eyes.2 We agree with the authors on the importance of an accurate ophthalmic examination in patients with DM1, because they may present with many ophthalmic diseases across the life span. However, we believe it is important to put their findings into context with other large studies.

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