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Comment & Response
December 2018

Clarification on Uveal Melanoma Associated With Myotonic Dystrophy

Author Affiliations
  • 1Department of Geriatrics, Orthopaedic and Neuroscience, Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy
  • 2Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
JAMA Ophthalmol. 2018;136(12):1426-1427. doi:10.1001/jamaophthalmol.2018.4056

To the Editor We read with interest the article by Dalvin et al1 on a retrospective analysis of a series of cases collected over 18 years of concurrent diagnosis for myotonic dystrophy type 1 (DM1) and uveal melanoma. The authors identified 6 cases that manifested this association, all of which presented typical clinical muscle symptoms of DM1, and they confirmed molecular diagnosis in 4 of them. Four of these 6 individuals had a family history of both DM1 and tumors. Given its rarity in the general population and the support of previous observations, the authors1 emphasized an increased risk for this highly aggressive eye cancer in patients with DM1, which means that they require periodic ophthalmologic screening.

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