To the Editor We read with interest the article by Dalvin et al1 on a retrospective analysis of a series of cases collected over 18 years of concurrent diagnosis for myotonic dystrophy type 1 (DM1) and uveal melanoma. The authors identified 6 cases that manifested this association, all of which presented typical clinical muscle symptoms of DM1, and they confirmed molecular diagnosis in 4 of them. Four of these 6 individuals had a family history of both DM1 and tumors. Given its rarity in the general population and the support of previous observations, the authors1 emphasized an increased risk for this highly aggressive eye cancer in patients with DM1, which means that they require periodic ophthalmologic screening.
Silvestri G, Rossi S, Perna A. Clarification on Uveal Melanoma Associated With Myotonic Dystrophy. JAMA Ophthalmol. 2018;136(12):1426–1427. doi:10.1001/jamaophthalmol.2018.4056
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: