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Comment & Response
December 2018

Clarification on Uveal Melanoma Associated With Myotonic Dystrophy—Reply

Author Affiliations
  • 1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
  • 2Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota
  • 3Department Molecular Medicine, Mayo Clinic, Rochester, Minnesota
JAMA Ophthalmol. 2018;136(12):1427. doi:10.1001/jamaophthalmol.2018.4184

In Reply We appreciate the important points raised by our colleagues in Italy, Rosa et al and Silvestri et al, regarding the association between uveal melanoma and myotonic dystrophy.1 Detecting an association between 2 rare diseases can present a challenge. We cited a prior publication from Win et al2 describing a 28-fold increased risk of uveal melanoma in patients with myotonic dystrophy, based on the detection of 2 cases in 307 patients. We then presented 6 additional cases, exemplifying this association.1 The letter from Rosa et al and a study by Bianchi et al3 describe no cases of uveal melanoma in 268 and 255 Italian patients, respectively.

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