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Invited Commentary
January 2019

Disorganization of Retinal Inner Layers and the Importance of Setting Boundaries

Author Affiliations
  • 1Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • 2Vienna Reading Center, Vienna, Austria
JAMA Ophthalmol. 2019;137(1):46-47. doi:10.1001/jamaophthalmol.2018.4516

The visualization of structural retinal changes has brought a new dimension to how vitreoretinal diseases are assessed and treated. The advent of optical coherence tomography (OCT) prompted numerous efforts to find, characterize, and validate morphologic biomarkers. These biomarkers are an important prerequisite to developing an automated image analysis that could eliminate subjective errors and provide ophthalmologists with objective measurements. In this issue of JAMA Ophthalmology, Babiuch et al1 report the results of a retrospective review in which they examined whether disorganization of retinal inner layers (DRIL) at baseline and after anti–vascular endothelial growth factor (anti-VEGF) treatment in a cohort of 147 patients with branch, central, and hemispheric retinal vein occlusion (RVO) was associated with visual acuity.

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