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Ophthalmic Images
November 8, 2018

Long-term Minocycline Therapy With Scleral Pigmentation Simulating Melanocytosis

Author Affiliations
  • 1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
JAMA Ophthalmol. 2018;136(11):e183088. doi:10.1001/jamaophthalmol.2018.3088

A white man in his 70s who had undergone previous radiotherapy for choroidal melanoma in the right eye developed unrelated cutaneous mycosis fungoides and secondary follicular mucinosis. The patient was treated with minocycline hydrochloride, 100 mg twice daily, for 15 years. External examination revealed newly detected blue-gray scleral pigmentation in all quadrants of both eyes, especially anterior to the horizontal rectus insertions, simulating melanocytosis (Figure). Observation was advised.

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