Do patients with acute yellow fever infection present with positive ocular findings?
In this case series, 2 patients with acute yellow fever virus infection presented with bilateral increased choroidal thickness on ocular ultrasonography. One patient, who died after onset of the infection, also presented with bilateral 360° choroidal detachments and yellowish subretinal lesions; the other patient, previously vaccinated for yellow fever virus, presented with bilateral increased retinal venous congestion.
Hemodynamic instability or the direct result of viral infection might be associated with the positive ocular findings in these patients with yellow fever virus.
Yellow fever virus (YFV) is a reemerging, potentially lethal arboviral disease that has been occurring recently in Africa and South America. Poor levels of immunization have facilitated the viral spread in southeastern Brazil, leading to an unprecedented outbreak that started in late 2016. Although human cases have been linked to sylvatic mosquitoes, the concern is that YFV may spread to urban centers infested with Aedes aegypti and Aedes albopictus mosquitoes and start a true urban cycle.
To describe the ocular findings in patients with acute YFV infection.
Design, Setting, Participants
Two adults with an acute YFV infection in southeastern Brazil underwent an ophthalmologic and ocular ultrasonographic examination in early 2018.
Main Outcomes and Measures
Ocular findings in patients with acute YFV infection.
Both patients presented with increased choroidal thickness bilaterally seen on ocular ultrasonography. A man in his late 50s who had not been vaccinated previously also presented with bilateral, midperipheral, 360° choroidal detachment and yellowish subretinal lesions. After clinical deterioration and liver transplant, the man died. A woman in her early 30s who had been vaccinated previously for YFV presented with increased retinal venous congestion bilaterally. She was discharged with mild conjunctival chemosis and icterus.
Conclusions and Relevance
These reports describe different patterns of ocular findings associated with YFV acute infection. However, the exact mechanism involved in the retinal and choroidal findings remains unclear.
Vianello S, Silva de Souza G, Maia M, Belfort R, de Oliveira Dias JR. Ocular Findings in Yellow Fever Infection. JAMA Ophthalmol. Published online January 10, 2019. doi:10.1001/jamaophthalmol.2018.6408
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: