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Comment & Response
March 14, 2019

Implications of Birdshot-Like Uveitis on the Pathogenesis of Birdshot Chorioretinopathy—Reply

Author Affiliations
  • 1The Retina Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
  • 2Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
JAMA Ophthalmol. 2019;137(5):584-585. doi:10.1001/jamaophthalmol.2019.0220

In Reply We read with interest the letter from Sun et al regarding possible pathophysiologic implications of our article on birdshot-like chorioretinopathy associated with pembrolizumab treatment.1 In the article, we observed a single patient who was treated for cutaneous melanoma with a checkpoint-inhibitor agent directed against the programmed cell death-1 receptor on T cells and soon thereafter developed a classic-appearing case of birdshot chorioretinopathy (BCR) in both eyes. Testing for HLA-A29 was negative. We speculated that this immunotherapy was associated with the development of clinical features of BCR.

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