[Skip to Content]
[Skip to Content Landing]
Views 702
Citations 0
Brief Report
May 2, 2019

Diffuse Uveal Melanocytic Proliferation With Primary Vitreoretinal Lymphoma

Author Affiliations
  • 1Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
  • 2Department of Ophthalmology, SUNY (State University of New York) Downstate Medical Center, Brooklyn
JAMA Ophthalmol. 2019;137(7):834-837. doi:10.1001/jamaophthalmol.2019.0905
Key Points

Question  Can diffuse uveal melanocytic proliferation occur secondary to primary vitreoretinal lymphoma?

Findings  In this case study of a patient who presented with uveal melanocytic proliferation, no systemic malignant disease was found, and the presence of primary vitreoretinal lymphoma was confirmed using chorioretinal biopsy findings.

Meaning  Primary vitreoretinal lymphoma may manifest with diffuse uveal melanocytic proliferation.


Importance  Bilateral diffuse uveal melanocytic proliferation is a rare sign of several systemic malignant neoplasms.

Observations  A patient presenting with uveal melanocytic proliferation underwent a detailed physical examination and extensive imaging. No systemic malignant neoplasm was found. Chorioretinal biopsy was performed, and its immunohistochemical results revealed the presence of primary vitreoretinal lymphoma.

Conclusions and Relevance  This patient’s results suggest that diffuse uveal melanocytic proliferation may be associated not just with systemic malignant disease, but also with primary intraocular tumors, in this case a primary vitreoretinal lymphoma.