Can diffuse uveal melanocytic proliferation occur secondary to primary vitreoretinal lymphoma?
In this case study of a patient who presented with uveal melanocytic proliferation, no systemic malignant disease was found, and the presence of primary vitreoretinal lymphoma was confirmed using chorioretinal biopsy findings.
Primary vitreoretinal lymphoma may manifest with diffuse uveal melanocytic proliferation.
Bilateral diffuse uveal melanocytic proliferation is a rare sign of several systemic malignant neoplasms.
A patient presenting with uveal melanocytic proliferation underwent a detailed physical examination and extensive imaging. No systemic malignant neoplasm was found. Chorioretinal biopsy was performed, and its immunohistochemical results revealed the presence of primary vitreoretinal lymphoma.
Conclusions and Relevance
This patient’s results suggest that diffuse uveal melanocytic proliferation may be associated not just with systemic malignant disease, but also with primary intraocular tumors, in this case a primary vitreoretinal lymphoma.
Leskov I, Lyon AT, Jampol LM. Diffuse Uveal Melanocytic Proliferation With Primary Vitreoretinal Lymphoma. JAMA Ophthalmol. Published online May 02, 2019137(7):834–837. doi:10.1001/jamaophthalmol.2019.0905
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