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Invited Commentary
June 27, 2019

Use of Corneal Biomechanical Measures as Endophenotypes for Understanding the Genetics of Keratoconus

Author Affiliations
  • 1Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
JAMA Ophthalmol. 2019;137(9):1013-1014. doi:10.1001/jamaophthalmol.2019.2068

Keratoconus is one of the most common causes of visual impairment in young adults and is the leading indication for corneal grafts in many jurisdictions.1 Prevalence estimates vary greatly between studies and ethnic groups but reach as high as 3.3% in some populations.2 Despite its prevalence and significant effect on the vision of teenagers and adults of working age, little is known about the etiology of keratoconus when compared with other causes of visual loss.

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