Keratoconus is one of the most common causes of visual impairment in young adults and is the leading indication for corneal grafts in many jurisdictions.1 Prevalence estimates vary greatly between studies and ethnic groups but reach as high as 3.3% in some populations.2 Despite its prevalence and significant effect on the vision of teenagers and adults of working age, little is known about the etiology of keratoconus when compared with other causes of visual loss.
Burdon KP. Use of Corneal Biomechanical Measures as Endophenotypes for Understanding the Genetics of Keratoconus. JAMA Ophthalmol. Published online June 27, 2019137(9):1013–1014. doi:10.1001/jamaophthalmol.2019.2068
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