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June 27, 2019

Capturing Macular Vascular Development in an Infant With Retinopathy of Prematurity

Author Affiliations
  • 1Department of Ophthalmology, Duke University, Durham, North Carolina
  • 2Department of Biomedical Engineering, Duke University, Durham, North Carolina
JAMA Ophthalmol. 2019;137(9):1083-1086. doi:10.1001/jamaophthalmol.2019.2165

Histopathological studies by Mann,1 Provis,2 Provis and Hendrickson,3 and Gariano and Gardner4 laid the foundation for our current understanding of human macular development. Primary retinal vasculature enters the retina from the optic disc at around 14 weeks’ gestation and migrates outward toward the periphery in a lobular fashion.2 The temporal notch forms at the temporal vascular front as a result of this lobular growth. This resembles the commonly observed immature vascular pattern in the posterior pole in prematurely born infants noted during retinopathy of prematurity (ROP) screening.