To the Editor The recent article by Shukla et al1 suggests that retinopathy of prematurity risk increases significantly with higher oxygen targets in infants who are premature. We wonder if higher oxygen targets also influenced the incidence of apnea of prematurity episodes and hence the administration of caffeine. This may be of interest, because some evidence from animal studies suggests that caffeine citrate can protect against hyperoxia-induced retinopathy.2,3 Different oxygen targets might alter the length of treatment with caffeine. Could the authors evaluate the data of this study to determine if episodes of apnea and the total amount of caffeine administered influenced mortality or retinopathy rates?
Jen R, Puusepp-Benazzouz H, Nanan R. Oxygen Saturation in Infants With Retinopathy of Prematurity. JAMA Ophthalmol. Published online July 11, 2019137(9):1092. doi:10.1001/jamaophthalmol.2019.2555
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