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JAMA Ophthalmology Clinical Challenge
September 12, 2019

Bilateral Limbus-Sparing Conjunctivitis in a Boy With Rash and Pneumonia

Author Affiliations
  • 1Yale School of Medicine, New Haven, Connecticut
  • 2Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston
JAMA Ophthalmol. Published online September 12, 2019. doi:10.1001/jamaophthalmol.2019.3137

An adolescent boy presented to the hospital with bilateral eye redness, an erythematous chest rash, lip blistering, and worsening sore throat for 2 days while undergoing a 10-day outpatient treatment course of ciprofloxacin and trimethoprim-sulfamethoxazole for community-acquired pneumonia. He complained of a cough, sore throat, and ocular itching. He denied prior ocular history and reported no visual changes. He had no significant medical history aside from documented allergies to β-lactam, macrolide, and cephalosporin antibiotics resulting in rashes, angioedema, and hives.